ParkinsonCanadaV1, Main, Exploration, bibRecord, 002110

Differences between subacute and chronic MPTP mice models: investigation of dopaminergic neuronal degeneration and α-synuclein inclusions

Identifieur interne : 002110 ( Main/Exploration ); précédent : 002109; suivant : 002111

Differences between subacute and chronic MPTP mice models: investigation of dopaminergic neuronal degeneration and α-synuclein inclusions

Auteurs : Claire Gibrat [Canada] ; Martine Saint-Pierre [Canada] ; Mélanie Bousquet [Canada] ; Daniel Levesque [Canada] ; Claude Rouillard [Canada] ; Francesca Cicchetti [Canada]

Source :

Journal of neurochemistry [ 0022-3042 ] ; 2009.

RBID : Pascal:09-0239780

Descripteurs français

Pascal (Inist)
- Chronique, Modèle animal, Dégénérescence, Rodentia, Mâle, Aigu, Traitement, Corps strié, Maladie de Parkinson, Tyrosine, Protéine, Cytoplasme, Neurone, Souris, Facteur transcription Nurr1.

English descriptors

KwdEn :
- Acute, Animal model, Chronic, Corpus striatum, Cytoplasm, Degeneration, Male, Mouse, Neuron, Nurr1 transcription factor, Parkinson disease, Protein, Rodentia, Treatment, Tyrosine.

Abstract

Animal models are invaluable tools to study neurodegenerative disorders but a general consensus on the most accurate rodent model of Parkinson's disease has not been reached. Here, we examined how different methods of MPTP administration influence the degeneration of the dopaminergic (DA) system. Adult male C57BU6 mice were treated with the same cumulative dose of MPTP following four distinct procedures: (i) sub-acute i.p. injections; (ii) 28-day chronic s.c. infusion; (iii) 28-day chronic i.p. infusion; and (iv) 14-day chronic i.p. infusion. Sub-acute MPTP treatment significantly affected all aspects of the DA system within the nigral and striatal territories. In contrast, the 28-day chronic s.c. infusion did not significantly alter any components of the DA system. The 28- and 14-day chronic i.p. infusions induced loss of tyrosine hydroxylase (TH)-positive cells correlated with a decrease in Nurr1 mRNA levels, but no significant decrease in the density of TH striatal fibers. Importantly, however, only the 14-day chronic MPTP i.p. infusion protocol promoted the formation of neuronal inclusions as noted by the expression of α-synuclein protein within the cytoplasm of TH nigral neurons. Overall, we found that the 14-day chronic MPTP i.p. infusion reproduces more accurately the pathological characteristics of early stage Parkinson's disease.

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Animal models are invaluable tools to study neurodegenerative disorders but a general consensus on the most accurate rodent model of Parkinson's disease has not been reached. Here, we examined how different methods of MPTP administration influence the degeneration of the dopaminergic (DA) system. Adult male C57BU6 mice were treated with the same cumulative dose of MPTP following four distinct procedures: (i) sub-acute i.p. injections; (ii) 28-day chronic s.c. infusion; (iii) 28-day chronic i.p. infusion; and (iv) 14-day chronic i.p. infusion. Sub-acute MPTP treatment significantly affected all aspects of the DA system within the nigral and striatal territories. In contrast, the 28-day chronic s.c. infusion did not significantly alter any components of the DA system. The 28- and 14-day chronic i.p. infusions induced loss of tyrosine hydroxylase (TH)-positive cells correlated with a decrease in Nurr1 mRNA levels, but no significant decrease in the density of TH striatal fibers. Importantly, however, only the 14-day chronic MPTP i.p. infusion protocol promoted the formation of neuronal inclusions as noted by the expression of α-synuclein protein within the cytoplasm of TH nigral neurons. Overall, we found that the 14-day chronic MPTP i.p. infusion reproduces more accurately the pathological characteristics of early stage Parkinson's disease.</div>
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Differences between subacute and chronic MPTP mice models: investigation of dopaminergic neuronal degeneration and α-synuclein inclusions

Differences between subacute and chronic MPTP mice models: investigation of dopaminergic neuronal degeneration and α-synuclein inclusions

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri